cpn10 isolated polypeptide, isolated nucleic acid, expression construct, host cell, antibody, pharmaceutical composition, method for treating or preventing a disease, method for modulating prr signaling, method for modulating the production and / or secretion of one or more immunomodulators, method for inhibiting production and / or secretion of one or more immunomodulators, method of identifying a compound that binds to a polypeptide, method for screening a coprote and a prr ligand and functional variant, derivative, homologue, analog or polypeptide fragment
ANDREW LEIGH JAMES,CHRISTOPHER JOHN DE BAKKER,CHRISTOPHER BRUCE HOWARD,DANIEL SCOTT LAMBERT,DEAN JASON NAYLOR,JEANETTE ELIZABETH STOK,KYLIE JANE RALSTON,LINDA ALISSON WARD,RICHARD JAMES BROWN,WALTER R
申请号：
BRPI0911676
公开号：
BRPI0911676A2
申请日:
2009.04.09
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
The present invention relates to isolated Cpn10 polypeptides possessing an increased affinity for a PRR ligand compared to Ala Cpn10 polypeptide. In a further embodiment, the present invention also relates to modified chaperonin 10 polypeptides, and to nucleic acids encoding the same and to compositions comprising such polypeptides and uses thereof.
