PROCÉDÉ DE FABRICATION DE CRISTAUX D'ACIDE 2-(3-CYANO-4-ISOBUTYLOXYPHÉNYL)-4-MÉTHYL-5-THIAZOLECABOXYLIQUE POLYMORPHIQUE PAR UNE MÉTHODE D'ADDITION D'UN SOLVANT MÉDIOCRE

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专利权人:

TEIJIN PHARMA LIMITED

发明人:

UEMURA, AKIHITO,NOGATA, TOMOAKI,TAKEYASU, TAKUMI

申请号：

EP10799952

公开号：

EP2455372A4

申请日:

2010.07.14

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

Disclosed is a process for producing A-form crystals of 2-(3-cyamo-4-isobutytoxyphenyl)-4-methyl-5-thiazotecarboxylic acid, comprising: a step of dissolving by heating 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid in one or a plurality of solvents as a good solvent, selected from the group consisting of 1-propmol, 2-propanol, ethanol, and acetone, a step of cooling the solution； and a step of adding to the solution a hydrocarbon solvent as a poor solvent.

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