Rather than using a coaxial cable, a twisted pair of wires is provided for each element-to-beamformer connection. Differential mode signals are transmitted between the transducer element and the respective channel. A multi-layer element is used for operation with the differential mode signals. In catheters or other probes, coaxial cables are not used. Using differential mode signals over twisted pairs allows reduction or rejection of common mode cross-talk and/or interference.