The present invention provides a novel sirtuin-1 activator and a preparation containing it for inhibiting cell aging caused by oxidative stress. The present invention provides a deacetylating enzyme-1 activator and a preparation containing the same for inhibiting cell aging caused by oxidative stress. The deacetylating enzyme-1 activator is characterized by containing peonydanum Thunb.) plants or their solvent extracts.本發明提供一種新穎去乙醯化酶(Sirtuin)-1活化劑、及含有其之用以抑制因氧化壓力引起之細胞老化的製劑。本發明提供一種去乙醯化酶-1活化劑、及含有其之用以抑制因氧化壓力引起之細胞老化的製劑，該去乙醯化酶-1活化劑之特徵在於包含牡丹防風(Peucedanum japonicum Thunb.)之植物體或其溶劑萃取物。
