Provided are: a novel Sirtuin-1 activator； and a preparation for preventing the occurrence of oxidative stress-induced cellular senescence, which contains the Sirtuin-1 activator. The present invention provides: a Sirtuin-1 activator which is characterized by comprising a body of a plant Peucedanum japonicum Thunb. or an extract thereof with a solvent； and a preparation for preventing the occurrence of oxidative stress-induced cellular senescence, which contains the Sirtuin-1 activator.本發明提供一種新穎去乙醯化酶(Sirtuin)-1活化劑、及含有其之用以抑制因氧化壓力引起之細胞老化的製劑。本發明提供一種去乙醯化酶-1活化劑、及含有其之用以抑制因氧化壓力引起之細胞老化的製劑，該去乙醯化酶-1活化劑之特徵在於包含牡丹防風(Peucedanum japonicum Thunb.)之植物體或其溶劑萃取物。
