GODESSART MARINA, NURIA,PIZCUETA LALANZA, MARIA PILAR
申请号：
PE2011001295
公开号：
PE20120552A1
申请日:
2010.01.19
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
It refers to a pharmacological mixture, including: (a) a first-class non hepatotoxic DHODH inhibitor, wherein R1 is h, halogen, C1-C4 tar, cycloquilo C3-C4, CF3, ocf3； R2 is h, halogen, C1-C4 tar； R3 is tetrazoline, COOH, so2nh2, among others； R4 is h, C1-C4 tar； R9 is h, phenyl； G1 is n, Cr6 is C4, C14, 1. Halide, cyclopropyl compound C3-C4, propoxyc1-c4, etc.； G2 is h, hydrogen Xi, halide, cyclopropyl compound C3-C4, 5-10 members of the heteroaromatic ring, single ring or bicycle, including one or more halogenated or non halogenated N atoms, cyclopropyl compound C4-C4, etc；(b) methamphetanone. The DHOD inhibitors selected were 1-oxidation 5 - (2-carboxi-4-cycloacrylonitrile) - 3-methyl-2-phenylpyridine； acido 2 - (2 - (3-cycloacrylonitrile) pirimidin-5-ilamino) - 5-cycloacrylonitrile. This combination is very useful in the treatment of rheumatoid arthritis, amphibious colitis, multiple sclerosis and so on.REFERIDA A UNA COMBINACION FARMACEUTICA QUE COMPRENDE: A) UN INHIBIDOR DE DHODH NO HEPATOTOXICO DE FORMULA I, DONDE R1 ES H, HALOGENO, ALQUILO C1-C4, CICLOALQUILO C3-C4, CF3, OCF3； R2 ES H, HALOGENO, ALQUILO C1-C4； R3 ES TETRAZOLILO, COOH, -SO2NH2, ENTRE OTROS； R4 ES H, ALQUILO C1-C4； R9 ES H, FENILO； G1 ES N, CR6； R6 ES H, ALQUILO C1-C4, HALOGENO, CICLOALQUILO C3-C4, ALCOXI C1-C4, ENTRE OTROS； G2 ES H, HIDROXI, HALOGENO, CICLOALQUILO C3-C4, ANILLO HETEROAROMATICO DE 5-10 MIEMBROS, MONOCICLICO O BICICLICO QUE CONTIENE 1 O MAS ATOMOS DE N SUSTITUIDO O NO CON HALOGENO, ALQUILO CICLOALQUILO C4-C4, ENTRE OTROS； Y B) METOTREXATO. UN INHIBIDOR DE DHODH SELECCIONADO ES 1-OXIDO DE 5-(2-CARBOXI-4-CICLOPROPILFENILAMINO)-3-METIL-2-FENILPIRIDINA； ACIDO 2-(2-(3-CICLOPROPOXIFENIL)PIRIMIDIN-5-ILAMINO)-5-CICLOPROPILBENZOICO. DICHA COMBINACION ES UTIL EN EL TRATAMIENTO DE ARTRITIS REUMATOIDE ESPONDILITIS ANQUILOSANTE, ESCLEROSIS MULTIPLE, ENTRE OTROS
