ROTHSTEIN, David M.,MURPHY, Chris,WONG, Vivian,KAZO, Glen
申请号：
ES07839531
公开号：
ES2725023T3
申请日:
2007.10.12
申请国别(地区):
ES
年份:
2019
代理人:
摘要：
A superoxide dismutases mimetic for use in the treatment of oral mucositis in a subject in need, where the subject is receiving an anticancer treatment comprising radiotherapy and where the superoxide dismutases mimetic is a compound represented by the formula: ** Formula ** where, W is a pyridine residue； and two sets of two adjacent carbon atoms of the macrocycle independently form saturated, partially saturated or unsaturated U and V cycles or heterocycles having 3 to 20 carbon atoms； and where R1, R'1, R2, R'2, R3, R'3, R4, R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, R'9, R10 and R'10 each are independently selected from the group consisting of hydrogen, alkenyl, alkenylcycloalkenyl, alkenylcycloalkyl, alkyl, alkylcycloalkenyl, alkylcycloalkyl, alkynyl, aralkyl, aryl, cycloalkenyl, cycloalkyl, cycloalkyl, cycloalkyl, cycloalkyl, cycloalkyl, cycloalkyl, cycloalkyl, cycloalkyl, cycloalkyl, cycloalkyl, cycloalkyl, cycloalkyl, cycloalkyl, cycloalkyl, cycloalkyl, cycloalkyl, cycloalkyl, cycloalkyl, cycloalkyl, cycloalkyl, cycloalkyl, cycloalkyl, cycloalkyl, cycloalkyl, cycloalkyl, cycloalkyl, cycloalkyl, cycloalkyl, cycloalkyl and heterocyclyl, and aralkyl radicals and carbon-linked radicals in α or α-amino acids； where M is a cation of a transition metal； and where X, Y and Z are independently selected from the group consisting of halide, oxo, aqueous, hydroxyl, alcohol, phenol, dioxygen, peroxo, hydroperox, alkylperoxo, arylperoxo, ammonium, alkylamino, arylamino, heterocycloalkylamino, heterocycloarylamino, aminoxides, hydrazino , alkylhydrazino, arylhydrazino, nitric oxide, cyanide, cyanate, thiocyanate, isocyanate, isothiocyanate, alkylnitrile, arylnitrile, alkylisonitrile, arylisonitrile, nitrate, nitrite, azido, alkylsulfonic acid, arylsulfonic acid, alkylsulfoic acid, alkylsulfoic acid, alkylsulfoic acid, alkylsulfoic acid, alkylsulfoic acid, alkylsulfoic acid, alkylsulfoic acid, alkylsulfoic acid, alkylsulfoic acid, alkylsulfoic acid, alkylsulfoic acids, al
