Leslie B. Gordon,Mark W. Kieran,Monica E. Kleinman
申请号：
US14209197
公开号：
US09381203B2
申请日:
2014.03.13
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Provided herein are combination therapies for the treatment of progeroid diseases and conditions, cellular aging, bone diseases, and cardiovascular diseases. The provided combination therapies target the aberrant farnesylation of the mutant lamin A protein progerin, and inhibit farnesyl biosynthesis, lamin A prenylation, and increase progerin clearance.
