Tethering Cysteine Residues Using Cyclic Disulfides

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专利权人:

Brandeis University

发明人:

Jeffrey N. Agar,Joseph Salisbury

申请号：

US16882035

公开号：

US20200283753A1

申请日:

2020.05.22

申请国别(地区):

US

年份:

2020

代理人:

摘要：

Described herein are compounds and methods for tethering proteins. For example, dimers of proteins, including SOD1 and DJ-1, are described, where the dimers are formed by the covalent bonding of a cysteine on the first monomer to a cysteine on the second monomer via a cyclic disulfide linker. The covalently attached dimers exhibit increased stabilization.

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