Tethering cysteine residues using cyclic disulfides

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专利权人:

Brandeis University

发明人:

Jeffrey N. Agar,Joseph Salisbury

申请号：

US14440978

公开号：

US09428589B2

申请日:

2013.11.15

申请国别(地区):

US

年份:

2016

代理人:

摘要：

Described herein are compounds and methods for tethering proteins. For example, dimers of proteins, including SOD1 and DJ-1, are described, where the dimers are formed by the covalent bonding of a cysteine on the first monomer to a cysteine on the second monomer via a cyclic disulfide linker. The covalently attached dimers exhibit increased stabilization.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/