HIMMELSBACH, FRANK,LANGKOPF, ELKE,JUNG, BIRGIT,BAUM, ANKE,SOLCA, FLAVIO,METZ, THOMAS
申请号：
DK06116986
公开号：
DK1731511T3
申请日:
2000.06.16
申请国别(地区):
DK
年份:
2015
代理人:
摘要：
Substituted amino-quinoline and amino-quinazoline derivatives are new. Substituted amino-quinoline and amino-quinazoline derivatives of formula (I) and their tautomers, stereoisomers and salts are new. [Image] R aH or 1-4C alkyl； R bPh, Ph-CH 2-, or -CH(Ph)-CH 3-； Ph : phenyl substituted by R 1-R 3； R 1, R 2H, halo, 1-4C alkyl, OH, 1-4C alkoxy, 3-6C cycloalkyl, 4-6C cycloalkoxy, 2-5C alkenyl, 2-5C alkynyl, Ar, Ar-O-, Ar-CH 2-, Ar-O-CH 2-, 3-5C alkenyloxy, 3-5C alkynyloxy, 1-4C alkylthio, 1-4C alkyl-SO-, 1-4C alkyl-SO 2-, CF 3-S-, CF 3-SO-, CF 3-SO 2-, CH 3 or OCH 3 substituted with 1-3 F, C 2H 5 or OCH 2H 5 substituted by 1-5 F, CN, NO 2, NH 2, (1-4C alkyl)NH-, or (1-4C alkyl) 2N-； or R 1 + R 2 on adjacent C atoms : -CH = CH-CH=CH-, -CH=CH-NH- or -CH=N-NH-； R 3H, F, Cl, Br, 1-4C alkyl, CF 3, or 1-4C alkoxy； X : C(CN) or N； A : imino optionally substituted by 1-4C alkyl； B : C(O) or SO2； C : 1,3-allenylene, 1,1-vinylene or 1,2-vinylene (all optionally substituted by CF 3 or 1-2 CH 3), ethynylene, or 1,3-butadien-1,4-ylene optionally substituted by CF 3 or 1-4 CH 3； D : 1-8C alkylene, -CO-1-8C alkylene or -SO 2-1-8C alkylene (optionally substituted by 1-4F), -CO-O-1-8C alkylene, -CO-NR 4-1-8C alkylene, or -SO 2-NR 4-1-8C alkylene； or D : bond when attached to a C atom of E or CO or SO2 when attached to a N atom of E； E : NH 2, or (1-4C alkyl)NH-, (1-4C alkyl) 2N-, (2-4C alkyl)NH-, (1-4C alkyl)(2-4C alkyl)N- or (2-4C alkyl) 2N- (all substituted in the beta -, gamma - or delta -position by R 5), (3-7C cycloalkyl)NH- or (3-7C cycloalkyl-1-3C alkyl)NH- (all optionally N-substituted by 1-4C alkyl), NH 2 or (1-4C alkyl)NH- (all optionally N-substituted by tetrahydrofuran-3-yl, tetrahydropyran-(3 or 4)-yl, tetrahydrofuranylmethyl, 1-(tetrahydrofuran-3-yl)-piperidin-4-yl, 1-(tetrahydropyran-(3 or 4)-yl)-piperidin-4-yl, 3-pyrrolidinyl, 3- or 4-piperidinyl or 3- or 4-hexahydroazepinyl (all optionally substituted by 1-3 1-4C alkyl)), 4-7 membered alkyleneimino (optionally substi
