ELSON MADUREIRA PEIXOTO,FERNANDA BRITO DE CARVALHO,JOSÉ OTÁVIO CARRERA SILVA JUNIOR,ROSEANE MARIA RIBEIRO COSTA
申请号：
BR102018074968
公开号：
BR102018074968A2
申请日:
2018.11.30
申请国别(地区):
BR
年份:
2020
代理人:
摘要：
hydroxyethylcellulose gel containing microencapsulated extract of arrabidaea chica the present invention patent deals with technological development for optimization semi-solid formulation (gel) for topical application, using microencapsulation conditions, by spray drying, containing as an active agent the extract of arrabidaea chica . hydroxyethylcellulose was used as a polymer for the drying process. the obtaining of the microencapsulated extract of the pariri occurred from the solubilization of the crude extract (obtained by percolation) in a 70% (v / v) ethanolic solution and the addition of hec in the extract was in the concentration of 1.5% (w / v ). the operational parameters were: drying air inlet temperature (tge = 100ºc), drying air outlet temperature (tgs = 78ºc), extract feed flow rate (wsusp = 0.2 l / h), air pressure atomization (patm = 6 bar), atomization air flow (watm = 20 lpm) and drying air flow of 60 m3 / h. the studies carried out consisted of the physical-chemical characterization of the microencapsulated extract and the development and evaluation of the formulation without the addition of another thickening agent； preliminary gel stability. thus, the microcapsules containing the extract of a. chica was favorable as an intermediate product and has advantages in the final production of semi-solid gels.gel de hidroxietilcelulose contendo extrato microencapsulado de arrabidaea chica a presente patente de invenção trata do desenvolvimento tecnológico para otimização formulação semi-sólida (gel) para aplicação tópica, utilizando de condições de microencapsulação, por spray drying, contendo como agente ativo o extrato de arrabidaea chica. a hidroxietilcelulose foi utilizada como polímero para o processo de secagem. a obtenção do extrato microencapsulado do pariri ocorreu a partir da solubilização do extrato bruto (obtido por percolação) em uma solução etanólica 70% (v/v) e a adição de hec no extrato foi na concentração de 1,5% (p/v). os parâmetros op
