Eva Marie W. LINDHOLM,Lykke PEDERSEN,Steffen SCHMIDT
申请号：
US16477847
公开号：
US20190367920A1
申请日:
2018.01.10
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention relates to antisense oligonucleotides that are capable of modulating expression of NF-κB1 in a target cell. The oligonucleotides are complementary to mammalian NFKB1 pre-mRNA intron sequence. The present invention further relates to conjugates of the oligonucleotide and pharmaceutical compositions and methods for treatment of cancer, inflammation or autoimmune diseases using the oligonucleotide.
