USE OF LOW DOSES OF OLIGONUCLEOTIDES ANTISENSE TO TGF-BETA1 GENES IN THE TREATMENT OF TUMORS

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专利权人:

发明人:

申请号：

EP08173070.7

公开号：

EP2062586B1

申请日:

2006.05.04

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

Use of at least one oligonucleotide with a length of from 8 to 30 nucleotide building blocks for manufacturing a pharmaceutical preparation for the prophylaxis and/or the treatment of diseases, that are modulated by TGF-beta1, TGF-beta3, VEGF, interleukin-10, c-jun, c-fos, and/or prostaglandin E2 in a mammal, wherein said oligonucleotide hybridizes with a messenger RNA of a TGF-beta1, TGF-beta3, VEGF, interleukin-10, c-jun, c-fos and/or prostaglandin E2 gene and wherein said preparation comprises said oligonucleotide in a concentration of about 1 microM to about 25 microM.

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