A physiological signal monitoring system comprising a pendant and a patch. The pendant includes a system on a chip (SoC) having a data store and a processor. The patch includes a cradle and electrodes mechanically and electrically connected with a flexible printed circuit board (PCB). When removably coupled with the cradle of the patch, the pendant receives from the electrodes electrical signals from a patient's heart and either stores the signals to the data store or transmits the signals to a remote computing device. A single channel patch configuration includes two electrodes positioned at least 8.0 centimeters (CM) apart. A two channel patch configuration employs three electrodes similarly spaced. Removable auxiliary components may connect to the pendant's device interfaces, each configured to receive physiological input such as electromyogram (EMG), electroencephalogram (EEG), body temperature, heart rate, pedometer, blood pressure, pulse oximetry, respiratory rate, posture/body orientation, and sleep monitoring.
