A device for arboreal plant endotherapy comprises: a hollow cylinder (1) provided with a piston (2), means (3) for actuating the motion of the piston (2), at least an injection needle (41, 42, 43, 44) and means (4) for connecting the needle (41, 42, 43, 44) to the cylinder (1), to inject into the trunk of a plant at least a dose of a phytotherapeutic formulation loaded into the cylinder (1). A central processing unit (CPU) automatically and intelligently controls the device, implementing a program which comprises a procedure for determining the dose (VDOS) of formulation to be administered to a plant and a procedure to control the means (3) for actuating the motion of the piston (2) according to the dose (VDOS) to be administered. A keyboard (TT) is connected to the central unit (CPU) to enter data manually and to manage the commands of the device. An analogue digital converter (A/D), connected to the central unit (CPU) and coupled to an input interface (II), receives signals coming from a displacement sensor (5) for the detection of the position of the piston (2) in the cylinder (1). The central processing unit (CPU) controls the means (3) for actuating the motion of the piston (2) through an output interface (IU) connected thereto. <IMAGE>