Provided are a resin tube (1) for a guide wire, a method for manufacturing a resin tube for a guide wire, and a guide wire, configured such that the resin tube (1) makes point contact in the axial direction with an object of contact at working site, thereby reducing frictional resistance and yielding excellent sliding properties, while also being prevented from kinking and collapsing, and having excellent buckling resistance. The resin tube (1) for a guide wire is characterized in that the outer shape of a cross-section (S10) perpendicular to the axial direction is polygonal, elliptic, or irregular, that the resin tube (1) is twisted in a helical shape about a deep inner-core hole (16) as the axis oftwisting (O1), the deep inner-core hole (16) extending in the axial direction and allowing a core wire to be inserted therein, and that the resin tube (1) is provided with a trunk section (10) having an undulation on the outer surface (12) caused by the twisted eccentric wall thickness.
