Toscano, John P.,Brookfield, Frederick Arthur,Cohen, Andrew D.,Courtney, Stephen Martin,Frost, Lisa Marie,Kalish, Vincent Jacob
申请号：
AU2016201037
公开号：
AU2016201037A1
申请日:
2016.02.19
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
#$%^&*AU2016201037A120160310.pdf#####YDROXYLSULFONAMIDE DERIVATIVES AS NEW PHYSIOLOGICALLY USEFUL NITROXYL DONORS ABSTRACT [0161] The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the Nhydroxysulfonamide derivatives.
