N-HYDROXYLSULFONAMIDE DERIVATIVES AS NEW PHYSIOLOGICALLY USEFUL NITROXYL DONORS

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专利权人:

Inc.;The Johns Hopkins University;Cardioxyl Pharmaceuticals, Inc.;Cardioxyl Pharmaceuticals

发明人:

Toscano, John P.,Brookfield, Frederick Arthur,Cohen, Andrew D.,Courtney, Stephen Martin,Frost, Lisa Marie,Kalish, Vincent Jacob

申请号：

AU2016201037

公开号：

AU2016201037A1

申请日:

2016.02.19

申请国别(地区):

AU

年份:

2016

代理人:

摘要：

#$%^&*AU2016201037A120160310.pdf#####YDROXYLSULFONAMIDE DERIVATIVES AS NEW PHYSIOLOGICALLY USEFUL NITROXYL DONORS ABSTRACT [0161] The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the Nhydroxysulfonamide derivatives.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/