Johns Hopkins University of School of Medicine;Cardioxyl Pharmaceuticals, Inc.
发明人:
Toscano, John P.,Brookfield, Frederick Arthur,Cohen, Andrew D.,Courtney, Stephen Martin,Frost, Lisa Marie,Kalish, Vincent Jacob
申请号：
AU2013201667
公开号：
AU2013201667A1
申请日:
2013.03.19
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
#$%^&*AU2013201667A120130411.pdf#####ABSTRACT [01611 The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the Nhydroxysulfonamide derivatives.
