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PROCÉDÉS DE PRÉPARATION DE VÉSICULES ET FORMULATIONS OBTENUES À PARTIR DE CELLES-CI
专利权人:
VARIATION BIOTECHNOLOGIES INC.
发明人:
申请号:
EP10797727.4
公开号:
EP2451950B1
申请日:
2010.07.06
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
The present disclosure provides methods for preparing vesicles. In some embodiments, the methods involve providing a molten mixture of vesicle forming lipids and then adding the molten mixture to an aqueous solution comprising an antigen such that antigen-containing vesicles are formed. In other embodiments, the methods involve providing a lyophilized lipid product and rehydrating the lyophilized lipid product with an aqueous solution comprising an antigen such that antigen-containing vesicles are formed. The lyophilized lipid product is prepared by melting vesicle-forming lipids to produce a molten lipid mixture and then lyophilizing the molten lipid mixture. The present disclosure also provides antigen-containing vesicle formulations prepared using these methods. The present disclosure also provides kits that include a lyophilized lipid product in a first container and an aqueous solution comprising an antigen in a second container.
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http://www.ckcest.cn/home/

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