Use of a trans-signaling approach in chimeric antigen receptors

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专利权人:

发明人:

Daniel J. Powell, Jr.,Carl H. June

申请号：

US14044569

公开号：

US10117896B2

申请日:

2013.10.02

申请国别(地区):

US

年份:

2018

代理人:

摘要：

The present invention provides compositions and methods for inducing a CAR mediated trans-signal in a T cell. The trans-signaling CAR T cells comprise a first CAR having a first signaling module and a second CAR having a distinct second signaling module. The present invention also provides cells comprising a plurality of types of CARs, wherein the plurality of types of CARs participate in trans-signaling to induce T cell activation.

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