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A CELL COMPRISING A CHIMERIC ANTIGEN RECEPTOR (CAR)
专利权人:
AUTOLUS LIMITED
发明人:
Shaun Cordoba,Evangelia Kokalaki,Martin Pulé,Simon Thomas,Shimobi Onuoha
申请号:
US16613343
公开号:
US20200188434A1
申请日:
2018.05.14
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The present invention provides a cell which comprises; (i) a chimeric antigen receptor (CAR) which comprises an antigen binding domain and an intracellular signalling domain; (ii) a membrane tethering component (MTC) which comprises a first dimerization domain; and (Hi) a signal-dampening component (SDC) comprising a signal-dampening domain (SDD) and a second dimerization domain which specifically binds the first dimerisation domain of the membrane-tethering component. Dimerisation between the MTC and SDC may be controllable with an agent, meaning that the agent can be used to control CAR-mediated cell signalling.
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