VANG Li (US),ВАНГ Ли (US),DOUERTI Dzhordzh (US),ДОУЭРТИ Джордж (US),VAN Silu (US),ВАН Силу (US),TAO Chzhi-fu (US),ТАО Чжи-фу (US),BRANKO Milan (US),БРАНКО Милан (US),KANZER Aaron R. (US),КАНЗЕР Аарон,VANG Li,ВАНГ Ли,DOUERTI Dzhordzh,ДОУЭРТИ Джордж,VAN Silu,ВАН Силу,TAO Chzhi-fu,ТАО Чжи-фу,BRANKO Milan,БРАНКО Милан,KANZER Aaron R.,КАНЗЕР Аарон Р.,UENDT Majkl D.,УЭНДТ Майкл Д.,SUN Syaokhun,СУН Сяоху
申请号：
RU2014119250
公开号：
RU0002625315C2
申请日:
2012.10.11
申请国别(地区):
RU
年份:
2017
代理人:
摘要：
FIELD: pharmacology.SUBSTANCE: invention relates to organic chemistry, namely a heterocyclic compound of formula (I) or to a therapeutically acceptable salt thereof, where X is benzo[d]thiazolyl, thiazolo[5,4-b]pyridinyl, thiazolo[4,5-c]pyridinyl, imidazo[1,2-a]pyridinyl, thiazolo[5,4-c]pyridinyl, thiazolo[4,5-b]pyridinyl, imidazo[1,2-a]pyrazinyl or imidazo[ 1,2-b]pyridazinyl； Y1 means pyrrolyl, pyrazolyl, triazolyl or pyridinyl； where Y1 is optionally substituted with 1 or 2 substituents independently selected from R5, CN and Cl； L1 is selected from (CR6R7)q, (CR6R7)s-O-(CR6R7)r, (CR6R7)s-S-(CR6R7)r, (CR6R7)s-S(O)2-(CR6R7)r and (CR6R7)s-NR6A-(CR6R7)r； Y2 means mono- or tricyclic C8-C10-cycloalkyl, spiro[2.5]octyl, spiro[3.5]nonyl, oxatricyclo[3.3.1.13,7]decyl or azabicyclo[3.2.1]octyl； where Y2 is optionally substituted with 1, 2 or 3 substituents independently selected from R8, OR8, SO2R8, CO(O)R8, OH and Br； Z1 is selected from , R1 and R3 are absent； R2 is deuterium or C1-C6-alkyl； R5 is C1-C6-alkyl； R6A is selected from hydrogen and C1-C6-alkyl； each R6 and R7 are hydrogen； R8 is selected from the group consisting of C1-C3-alkyl, morpholinyl and dioxydothiomorpholinyl； where R8, meaning C1-C6-alkyl, is optionally substituted with a substituent selected from R16, OR16, SO2R16 and NHR16； Rk is selected from C1-C6-alkyl, morpholinyl, cyclopropyl and C1-haloalkyl； R16 Is selected from C1-C4-alkyl, phenyl, morpholinyl and tetrahydropyranyl； where R16, meaning C1-C4-alkyl, is optionally substituted with 1 substituent selected from OCH3, OCH2CH2OCH3 and OCH2CH2NHCH3； q is 1 or 2； s, m and p is 0； r is 0 or 1； N is 0, 1, or 2. The invention also relates to specific compounds, pharmaceutical compositions based on these compounds and a method for treatment of these diseases.EFFECT: new heterocyclic compounds are obtained, that are useful for treatment of some cancers.16 cl, 3 tbl, 86 exИзобретение относится к области органической химии, а именно к гетероциклическому сое
