The Government of the United States of America; as represented by the Secretary; Department of Health and Human Services; Centers for Disease Control and Prevention
发明人:
Ades, Edwin W.,Sampson, Jacquelyn S.,Steiner, Sandra,Carlone, George M.,Caba, Joseph J.,Rajam, Gowrisankar
申请号：
AU2012201107
公开号：
AU2012201107A1
申请日:
2012.02.24
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2012201107A120120315.pdf#####ABSTRACT Provided is a P4 peptide, which contains functional epitopes of the PsaA protein of Streptococcus pneumoniae, and related methods 5 and compositions. A peptide that comprises the amino acid sequence defined in SEQ ID NO:1 (an example of the P4 peptide) is provided. Also provided is a peptide comprising the amino acid sequence defined as VPSLFVDSSVDDRPMKTVSQDTNIPIYAQIFTDS (SEQ ID NO:2). P4 peptide mimetics having a conformational structure identical or o similar to the conformation of P4 (e.g., SEQ ID NO:1 and SEQ ID NO:2) are provided. An antibody that specifically binds to the epitope defined by the disclosed peptides is provided. For example, the antibody can specifically bind to a peptide comprising the sequence set forth in SEQ ID NO:1 and having the conformation 5 defined by the peptide consisting of SEQ ID NO:1. An antibody that specifically binds to a peptide comprising the sequence set forth in SEQ ID NO:2 and having the conformation defined by the peptide consisting of SEQ ID NO:2 is also provided. A P4-specific antibody is PsaA-specific since P4 defines an epitope specific for PsaA. A o vaccine comprising the peptide of SEQ ID NO:1 and a pharmaceutical carrier is provided. A vaccine comprising a peptide of SEQ ID NO:2 and a pharmaceutical carrier is also provided. Methods of using the peptides and antibodies of the invention are provided. Diagnostic kits comprising a P4 peptide is also provided. 5 316805 1 (GHMatters) P78170.AU.1 24-Feb-12
