The provision of a method of manufacturing the same transmission and body in a water-soluble chitosan nanoparticles of the challenges anticancer agents. Relates to a method for manufacturing transmission and body in a water-soluble chitosan nanoparticles of the resolution means anticancer agents, using a water-soluble chitosan to the basic configuration of the anti-cancer mass transfer body, and negatively charged by the positive charge strong amine group of water-soluble chitosan By forming a complex with DNA has, to impart the ability to target a desired site by introducing functional groups other positions of the free amine groups are highly reactive excellent as a gene delivery carrier, the anti-cancer agent The method of manufacturing the same and a drug delivery body in the water-soluble chitosan nanoparticles efficiently. By introducing each of the hydrophilic and hydrophobic groups in the positions of the free amine group-reactive water-soluble chitosan is high, the transfer body in the water-soluble chitosan nanoparticles of the anticancer agent of the present invention can readily encapsulated anticancer agent paclitaxel, The water-soluble chitosan nano - redispersion ability superior, paclitaxel exhibit anti-cancer effects by accumulating many tumor cells. [Selection] Figure Figure 1【課題】抗癌剤の伝達体用水溶性キトサンナノ粒子及びその製造方法の提供。【解決手段】抗癌剤の伝達体用水溶性キトサンナノ粒子及びその製造方法に関し、抗癌物質伝達体の基本構成に水溶性キトサンを使用し、水溶性キトサンのアミン基の強い陽電荷により陰電荷を帯びたDNAと複合体を形成して、遺伝子伝達体としても優秀で反応性が高い遊離アミン基の位置に他の機能性基を導入して目的部位を標的できる機能を付与することで、抗癌剤の効率的な薬物伝達体用水溶性キトサンナノ粒子及びその製造方法を提供する。本発明の抗癌剤の伝達体用水溶性キトサンナノ粒子は、水溶性キトサンの反応性が高い遊離アミン基の位置に親水性基及び疎水性基をそれぞれ導入することで、抗癌剤パクリタキセルを容易に封入でき、この水溶性キトサンナノ-パクリタキセルは再分散能力がすぐれ、腫瘍細胞に多く蓄積して抗癌効果を示す。【選択図】図1
