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COMPOSITIONS AND METHODS FOR DELIVERING BIOTHERAPEUTICS
专利权人:
发明人:
Benjamin Pyles
申请号:
US15759788
公开号:
US20180346531A1
申请日:
2016.08.23
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Provided herein are compositions and methods relating to cell-penetrating conjugates for the delivery of therapeutic polypeptides or polynucleotides to cells or tissues of the body. The delivery conjugate comprises a cell-penetrating peptide and a nuclear localization signal sequence plus an effector moiety (such as a polypeptide or polynucleotide) as the payload, optionally further including an epitope tag as well as a solubility peptide and a configurating peptide. The delivery conjugate can also include a component capable of specifically directing the conjugate to a target cell or tissue, making the conjugate effective for treating diseases in the target tissue.
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