Christoph Burdack,Cédric Kalinski,Guenther Ross,Lutz Weber,Vladimir Khazak
申请号：
BRPI0918603
公开号：
BRPI0918603A2
申请日:
2009.09.15
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
The present invention provides compounds of formula (I) or (Ia) which are ligands binding to the HDM2 protein, inducing apoptosis and inhibiting proliferation, and having therapeutic utility in cancer therapy and prevention. Compounds of formula (I) or (Ia) can be used as therapeutics for treating stroke, myocardial infarction, ischemia, multi-organ failure, spinal cord injury, Alzheimer's Disease, injury from ischemic events and heart valvular degenerative disease. Moreover, compounds of formula (I) or (Ia) can be used to decrease the side effects from cytotoxic cancer agents, radiation and to treat viral infections.
