KALINSKI CEDRIC,ROSS GUENTHER,WEBER LUTZ,KHAZAK VLADIMIR,BURDACK CHRISTOPH
申请号：
TN2011000051
公开号：
TN2011000051A1
申请日:
2011.01.28
申请国别(地区):
TN
年份:
2012
代理人:
摘要：
The present invention provides compounds of formula (I) or (Ia) which are ligands binding to the HDM2 protein, inducing apoptosis and inhibiting proliferation, and having therapeutic utility in cancer therapy and prevention. Compounds of formula (I) or (Ia) can be used as therapeutics for treating stroke, myocardial infarction, ischemia, multi-organ failure, spinal cord injury, Alzheimers Disease, injury from ischemic events and heart valvular degenerative disease. Moreover, compounds of formula (I) or (Ia) can be used to decrease the side effects from cytotoxic cancer agents, radiation and to treat viral infections.
