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Suspension formulations of insulinotropic peptides and uses thereof
专利权人:
Thomas R. Alessi;Catherine M. Rohloff;Ryan D. Mercer;Bing Yang
发明人:
Thomas R. Alessi,Ryan D. Mercer,Catherine M. Rohloff,Bing Yang
申请号:
US12148896
公开号:
US08299025B2
申请日:
2008.04.22
申请国别(地区):
US
年份:
2012
代理人:
摘要:
A suspension formulation of an insulinotropic peptide (e.g., glucagon-like peptide-1 (GLP-1) or exenatide) is described. The suspension formulation comprises (i) a non-aqueous, single-phase vehicle, comprising one or more polymer and one or more one solvent, wherein the vehicle exhibits viscous fluid characteristics, and (ii) a particle formulation comprising the insulinotropic peptide, wherein the peptide is dispersed in the vehicle. The particle formulation further includes a stabilizing component comprising one or more stabilizers, for example, carbohydrates, antioxidants, amino acids, and buffers. Devices for delivering the suspension formulations and methods of use are also described.
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