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SUSPENSION FORMULATIONS OF INSULINOTROPIC PEPTIDES AND USES THEREOF
专利权人:
发明人:
ALESSI THOMAS R.,MERCER RYAN D.,ROHLOFF CATHERINE M.,YANG BING
申请号:
IN6267/DELNP/2009
公开号:
IN270290B
申请日:
2009.09.30
申请国别(地区):
IN
年份:
2015
代理人:
摘要:
A suspension formulation of an insulinotropic peptide (e.g., glucagon-like peptide- 1 (GLP-1) or exenatide) is described. The suspension formulation comprises (i) a non aqueous, single-phase vehicle, comprising one or more polymer and one or more one solvent, wherein the vehicle exhibits viscous fluid characteristics, and (ii) a particle formulation comprising the insulinotropic peptide, wherein the peptide is dispersed in the vehicle. The particle formulation further includes a stabilizing component comprising one or more stabilizers, for example, carbohydrates, antioxidants, amino acids, and buffers. Devices for delivering the suspension formulations and methods of use are also described.
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