This application relates to recombinant human interferon-like proteins. In one embodiment a recombinant protein created by gene shuffling technology is described having enhanced anti-viral and anti-proliferative activities in comparison to naturally occurring human interferon alpha 2b (HuIFN-±2b). The invention encompasses a polynucleotide encoding the protein and recombinant vectors and host cells comprising the polynucleotide. Preferably the polynucleotide is selected from the group of polynucleotides each having a sequence at least 93% identical to SEQ ID: No. 1 and the protein is selected from the group of proteins each having an amino acid sequence at least 85% identical to SEQ ID No: 2. The proteins and compositions comprising the proteins can be used for treatment of conditions responsive to interferon therapy, such as viral diseases and cancer.本申請涉及重組人干擾素樣蛋白。在一個實施方案中，描述了通過基因改組技術獲得的重組蛋白，其具有相比天然存在的人干擾素α2b(HuIFN－α2b)而言增強的抗病毒和抗增殖活性。本發明包括編碼所述蛋白質的多核苷酸以及含有該多核苷酸的重組載體和宿主細胞。優選地，所述多核苷酸選自其中每個多核苷酸具有與SEQ ID No：1至少93%同一的序列的多核苷酸的組，和所述蛋白質選自其中每個蛋白質具有與SEQ ID No：2至少85%同一的氨基酸序列的蛋白質的組。所述蛋白質和包含所述蛋白質的組合物可用於治療對干擾素療法作出回應的病狀，例如病毒疾病和腫瘤。
