Agonistic CD40 antibodies

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专利权人:

MAB Discovery GmbH

发明人:

FISCHER, Stephan,BECKMANN, Karsten

申请号：

AU2018335828

公开号：

AU2018335828A1

申请日:

2018.09.19

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

The present invention relates to humanized monoclonal antibodies or antigen-binding fragments thereof that specifically bind to human CD40 receptor and induce CD40 signaling independent of Fey mediated CD40 receptor crosslinking. The antibodies of the present invention bind to a CD40 epitope that overlaps with the epitope of the CD40 ligand and can activate human APCs. The present invention also provides for compositions comprising said antibodies and uses for the antibodies and compositions in the treatment of patients suffering from cancer.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/