Non-steroidal selective glucocorticoid receptor agonistic modulators (SEGRAMs) and uses thereof

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专利权人:

Association pour la Recherche à l'IGBMC (ARI)

发明人:

CHAMBON, Pierre,HUA, Guoqiang

申请号：

AU2018355698

公开号：

AU2018355698A1

申请日:

2018.10.23

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

The present invention relates to the two enantiomers of a SElective Glucocorticoid Receptor Agonistic Modulator (SEGRAM) of Formula 1 or a derivative thereof； to a deuterated form of a SEGRAM of Formula 1 or a derivative thereof； and to the two deuterated enantiomers of a SEGRAM of (Formula 1) or a derivative thereof: or a pharmaceutically acceptable salt, solvate and/or prodrug thereof. The present invention also relates to a SEGRAM of Formula 1 or a derivative thereof, or a pharmaceutically acceptable enantiomer, deuterated form, salt, solvate and/or prodrug thereof, for use in the prevention or treatment of an inflammatory disorder in a subject in need thereof.

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