Embodiments provide devices, systems and methods for preventing deep vein (DV) thrombosis (DVT). One embodiment provides a DVT prevention device comprising a cuff that fits over a patient's leg, an applanator coupled to an inside cuff surface, an expandable member (EM) coupled to the applanator, a pressure source fluidically coupled to the EM and a controller for controlling inflation of the EM. When the EM is expanded, it applies a force to the applanator which is transmitted by the applanator as a force to the leg surface which causes a DV under the cuff to be compressed so as to minimize blood flow through the DV. The EM is then deflated, stopping DV compression and blood flow resumes. The EM can be inflated in a cycle including pulsed inflation, inflation hold and relaxation. The cycles can be repeated and adjusted to achieve a desired increase of flow/velocity in the DV.
