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NOVEL TETRAHYDROISOQUINOLINE COMPOUNDS FOR THE TREATMENT OF OBESITY AND RELATED CONDITIONS
专利权人:
DAIICHI SANKYO COMPANY; LIMITED
发明人:
UTO, YOSHIKAZU,KARASAWA, HIROSHI,TAKAISHI, KIYOSUMI
申请号:
NZ59853510
公开号:
NZ598535A
申请日:
2010.08.27
申请国别(地区):
NZ
年份:
2013
代理人:
摘要:
The present disclosure relates to a compound or a pharmacologically acceptable salt thereof having an excellent DGAT inhibitory effect and feeding suppressant effect. The present disclosure provides trans-6-[3-(2,4-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester, trans-6-[3-(2-chloro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester, trans-6-[3-(2,3-difluorophenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid4-carboxymethyl-cyclohexyl ester, trans-6-[3-(2,5-difluorophenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester, trans-6-[3-(2,6-difluorophenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester, or the like, or a pharmacologically acceptable salt thereof. Also disclosed are compositions containing said compounds and their use in treating acyl-CoA mediated diseases.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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