The present invention relates to a compound or a pharmacologically acceptable salt thereof having an excellent DGAT inhibitory effect and feeding suppressant effect. The present invention provides trans-6-[3-(2,4-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester, trans-6-[3-(2-chloro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester, trans-6-[3-(2,3-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester, trans-6-[3-(2,5-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester, trans-6-[3-(2,6-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester, or the like, or a pharmacologically acceptable salt thereof.본 발명은 우수한 DGAT 저해 작용 및 섭식 억제 작용을 갖는 화합물 또는 그 약리상 허용되는 염에 관한 것이다.trans-6-[3-(2,4-디플루오로-페닐)-우레이도]-3,4-디하이드로-1H-이소퀴놀린-2-카르복실산 4-카르복시메틸-시클로헥실에스테르, trans-6-[3-(2-클로로-페닐)-우레이도]-3,4-디하이드로-1H-이소퀴놀린-2-카르복실산 4-카르복시메틸-시클로헥실에스테르, trans-6-[3-(2,3-디플루오로-페닐)-우레이도]-3,4-디하이드로-1H-이소퀴놀린-2-카르복실산 4-카르복시메틸-시클로헥실에스테르, trans-6-[3-(2,5-디플루오로-페닐)-우레이도]-3,4-디하이드로-1H-이소퀴놀린-2-카르복실산 4-카르복시메틸-시클로헥실에스테르, trans-6-[3-(2,6-디플루오로-페닐)-우레이도]-3,4-디하이드로-1H-이소퀴놀린-2-카르복실산 4-카르복시메틸-시클로헥실에스테르 등 또는 그 약리상 허용되는 염.
