Novel tetrahydroisoquinoline compounds

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专利权人:

Limited;Daiichi Sankyo Company

发明人:

Uto, Yoshikazu,Karasawa, Hiroshi,Takaishi, Kiyosumi

申请号：

AU2010287464

公开号：

AU2010287464A1

申请日:

2010.08.27

申请国别(地区):

AU

年份:

2012

代理人:

摘要：

Disclosed are compounds, which have excellent effects of inhibiting DGAT and suppressing food intake, or pharmacologically acceptable salts of the same. Specifically disclosed are 4-carboxymethyl-cyclohexyl trans-6-[3-(2,4-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylate, 4-carboxymethyl-cyclohexyl trans-6-[3-(2-chloro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylate, 4-carboxymethyl-cyclohexyl trans-6-[3-(2,3-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylate, 4-carboxymethyl-cyclohexyl trans-6-[3-(2,5-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylate, 4-carboxymethyl-cyclohexyl trans-6-[3-(2,6-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylate, etc., or pharmacologically acceptable salts of the same.

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