Abakumov Maksim Artemovich (RU),Абакумов Максим Артемович (RU),Semkina Alevtina Sergeevna (RU),Семкина Алевтина Сергеевна (RU),Chekhonin Vladimir Pavlovich (RU),Чехонин Владимир Павлович (RU),Mazhuga
申请号：
RU2019123980
公开号：
RU0002723894C1
申请日:
2019.07.30
申请国别(地区):
RU
年份:
2020
代理人:
摘要：
FIELD: pharmaceutics.SUBSTANCE: invention relates to chemical-pharmaceutical industry and a method for preparing a contrast agent for diagnosing neoplasms by magnetic resonance imaging (MRI) based on magnetic modified nanoparticles (MNP) of iron oxide Fe2O3. For this, by heating while stirring solution of iron (III) acetylacetonate in benzyl alcohol and its holding at the reached temperature, carried out in an atmosphere of an inert gas, followed by cooling of the obtained mixture to obtain a suspension of iron oxide nanoparticles, adding a suspension of a water-soluble polar organic solvent, separating the nanoparticles, resuspending them in an aqueous solution of alkali, mixing the obtained suspension with an aqueous alkaline solution of human serum albumin, incubating the mixture and cleaning, adding aqueous solution of glutaric aldehyde to the suspension, incubating the mixture, adding sodium borohydride solution to mixture, incubating mixture and cleaning it, using iron (III) acetylacetonate solution with concentration of 48–70 g/l, heating is carried out for 5–12 hours to temperature of 160–205 °C, holding at the achieved temperature is carried out for 1–60 minutes, and cooling of the obtained mixture is carried out in the presence of oxygen to obtain a suspension of Fe2O3 nanoparticles.EFFECT: invention allows prolonging the preparation storage life in 2 times both in the form of a suspension and in the form of a lyophilizate.1 cl, 4 dwg, 4 exИзобретение относится к химико-фармацевтической промышленности и касается способа получения контрастного препарата для диагностики новообразований методом магнитно-резонансной томографии (МРТ), выполненного на основе магнитных модифицированных наночастиц (МНЧ) оксида железа Fe2O3. Для этого путем нагрева при перемешивании раствора ацетилацетоната железа (III) в бензиловом спирте и его выдерживания при достигнутой температуре, проводимыми в атмосфере инертного газа, с последующим охлаждением полученной смеси с получением
