A MEDICINAL FUSIDIC ACID CREAM MADE USING SODIUM FUSIDATE AND INCORPORATING A BIOPOLYMER, BETAMETHASONE DIPROPIONATE, TERBINAFINE HYDROCHLORIDE AND A PROCESS TO MAKE IT
The present invention discloses a medicinal composition for treating skin inflammations, fungal/bacterial skin infections and related wounds, and also other skin wounds including those caused by burns. The cream also causes skin rejuvenation through an epithelisation process. The active ingredients, namely Chitosan, Betamethasone Dipropionate, Terbinafine Hydrochloride and Fusidic Acid. The invention also discloses a process to make the medicinal cream containing Fusidic Acid which is formed in situ from Sodium Fusidate as the starting raw material, wherein Sodium Fusidate is converted into Fusidic Acid under oxygen-free environment created using inert gas, preferably nitrogen, and Chitosan. The cream produced by the process of the present invention has greater shelf-life stability and the finer particle size of the API than the conventional creams containing Fusidic Acid. The cream produced by the process of the present invention contains Fusidic Acid as the API that has been formed in situ from Sodium Fusidate, Betamethasone Dipropionate & Terbinafine Hydrochloride in a cream base comprising a preservative, an acid, a co-solvent, an emulsifier and a waxy material along with water, preferably purified water.La présente invention concerne une composition médicinale destinée à traiter des inflammations de la peau, des infections fongiques/bactériennes de la peau et les plaies associées, et également dautres plaies au niveau de la peau, notamment celles provoquées par les brûlures. La crème permet également un renouvellement de la peau par le biais dun processus dépithélisation. Les principes actifs sont le chitosane, le dipropionate de bétaméthasone, le chlorhydrate de terbinafine et lacide fusidique. Linvention concerne également un procédé de fabrication de la crème médicinale contenant de lacide fusidique qui est formé in situ à partir du fusidate de sodium en tant que produit brut de départ, le fusidate de sodium étant converti en acide fusidique dans un environn
