TRON -Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz Gemeinnützige GmbH;BioNTech RNA Pharmaceuticals GmbH
Disclosed is a n individualised RNA cancer vaccine comprising RNA encoding a recombinant polyepitopic polypeptide comprising mutation based neo-epitopes, said neo-epitopes resulting from cancer specific somatic mutations identified in a tumor specimen of a cancer patient, wherein the RNA vaccine features a cancer mutation signature of the cancer patient. THe neo-epitopes are in their natural sequence context so as to form vaccine sequences comprising up to 50 amino acids, and the vaccine sequences are spaced by linkers comprising 3 to 50 amino acids consisting of (i) glycine amino acids or (ii) serine and glycine amino acids.
