Danielson, Michael E.,Kshirsagar, Tushar A.,Griesgraber, George W.,Slania, Sarah J.
申请号：
AU2005326708
公开号：
AU2005326708B2
申请日:
2005.12.29
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
Substituted fused [1,2]imidazo[4,5-] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a -CH(-R)- group in the fused ring at the 1-position of the imidazo ring, wherein R includes a functional group, for example, an amide, sulfonamide, urea, carbamate, ester, ketone, ether, a thio analog of the forgoing, sulfone, oxime, or hydroxylamine, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
