GRIESGRABER, GEORGE W.,KSHIRSAGAR, TUSHAR A.,SLANIA, SARAH J.,DANIELSON, MICHAEL E.
申请号:
CA2594674
公开号:
CA2594674C
申请日:
2005.12.29
申请国别(地区):
CA
年份:
2016
代理人:
摘要:
Substituted fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a -CH(-R1)- group in the fused ring at the 1-position of the imidazo ring,wherein Rl includes a functional group, for example, an amide, sulfonamide,urea, carbamate, ester, ketone, ether, a thio analog of the forgoing, sulfone,oxime, or hydroxylamine, pharmaceutical compositions containing the compounds,intermediates, methods of making the compounds, and methods of use of thesecompounds as immunomodulators, for inducing cytokine biosynthesis in animalsand in the treatment of diseases including viral and neoplastic diseases, aredisclosed.