Azim A. CELEBI;Michael E. DANIELSON;Tushar A. KSHIRSAGAR;Joshua R. WURST;George W. GRIESGRABER;Sarah J. SLANIA;Michael J. RICE
发明人:
George W. GRIESGRABER,Tushar A. KSHIRSAGAR,Azim A. CELEBI,Sarah J. SLANIA,Michael E. DANIELSON,Michael J. RICE,Joshua R. WURST
申请号：
US13480749
公开号：
US20120232057A1
申请日:
2012.05.25
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a —CH(—X1—R1)— group in the fused ring at the 1-position of the imidazo ring, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
