Tung Robert D.,Hale Michael R.,Baker Christopher T.,Furfine Eric Steven,Kaldor Istvan,Kazmierski Wieslaw Mieczyslaw,Spaltenstein Andrew
申请号：
LU91426
公开号：
LU91426I9
申请日:
2008.04.02
申请国别(地区):
LU
年份:
2018
代理人:
摘要：
The present invention relates to prodrugs of a class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of prodrugs of HIV aspartyl protease inhibitors characterized by favorable aqueous solubility, high oral bioavailability and facile in vivo generation of the active ingredient. This invention also relates to pharmaceutical compositions comprising these prodrugs. The prodrugs and pharmaceutical compositions of this invention are particularly well suited for decreasing the pill burden and increasing patient compliance. This invention also relates to methods of treating mammals with these prodrugs and pharmaceutical compositions.
