РОУ Джонатан (IE),КОГЛЭН Дэвид (IE),МАНКУ Мехар (IE)
申请号：
RU2014134720
公开号：
RU2014134720A
申请日:
2013.01.25
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A method of treating or preventing a microbial infection, comprising administering to a subject in need of a pharmaceutical composition comprising 15-hydroxyeycose-8 (Z), 11 (Z), 13 (E) -trienoic acid (15-HETrE) .2. A method according to claim 1, characterized in that the pharmaceutical composition is applied topically to the subject. A method according to claim 2, characterized in that the pharmaceutical composition is applied topically to the wound of a subject. A method according to any one of the preceding claims, characterized in that the microbial infection is a bacterial infection. A method according to any one of claims 1 to 3, characterized in that the microbial infection is a fungal infection. The method according to any one of paragraphs. 1-3, characterized in that the pharmaceutical composition is administered in an amount effective to treat or prevent microbial infection. The method according to any one of paragraphs. 1-3, characterized in that the pharmaceutical composition contains from about 0.1% of the mass. up to about 20% of the mass. 15-HETrE and one or more excipients. 8. The method according to any one of paragraphs. 1-3, characterized in that 15-HETrE is in the form of a free acid. The method according to any one of paragraphs. 1-3, characterized in that 15-NETgE is a pharmaceutically acceptable ester, derivative, conjugate or salt of 15-HETrE.10. The method according to any one of paragraphs. 1-3, characterized in that 15-HETrE is an alkyl ester of 15-HETrE. 11. The method according to any one of paragraphs. 1-3, characterized in that the pharmaceutical composition also contains an additional active agent selected from neomycin sulfate, polymyxin B, bacitracin-zinc, ampicillin, amoxicillin, imipenem, meropenem, carbapenems, cephalexin, cephalotin, cephalosin, cefuroxime, cefotaxime, cefotaxime fluoroquinolones, oxazolidinones, lincosamides, metronidazole, clinda1. Способ лечения или предотвращения микробной инфекции, включающий введение ну
