Methods and compositions for controlling efficacy of RNA silencing

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专利权人:

University of Massachusetts

发明人:

Zamore, Phillip D.,Tang, Guiliang

申请号：

AU2011254018

公开号：

AU2011254018A1

申请日:

2011.12.14

申请国别(地区):

AU

年份:

2012

代理人:

摘要：

#$%^&*AU2011254018A120120119.pdf#####ABSTRACT Based at least in part on an understanding of the mechanisms by which small RNAs (e.g., naturally-occurring miRNAs) mediate RNA silencing in plants, 5 rules have been established for determining, for example, the degree of complementarity required between an RNAi-mediating agent and its target, i.e., whether mismatches are tolerated, the number of mismatches tolerated, the effect of the position of the mismatches, etc. Such rules are useful, in particular, in the design of improved RNAi-mediating agents which allow for more exact 10 control of the efficacy of RNA silencing.

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