TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
发明人:
Kamel Khalili,Wenhui Hu
申请号：
US15764119
公开号：
US20190367910A1
申请日:
2016.09.23
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present disclosure provides compositions and methods for specific cleavage of target sequences in retroviruses, for example human immunodeficiency virus (HV-1). The compositions, which can include nucleic acids encoding a Clustered Regularly Interspace Short Palindromic Repeat (CRISPR) associated endonuclease and a guide RNA sequence complementary to a target sequence in a human immunodeficiency virus, can be delivered to the cells of a subject having or at risk for contracting an HV infection.
