DETECTION IN VIVO D'UNE MOLECULE-CAGE LIANT LE XENON

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专利权人:

LAKEHEAD UNIVERSITY

发明人:

ALBERT, MITCHELL,HANE, FRANCIS

申请号：

CA2968722

公开号：

CA2968722A1

申请日:

2017.05.30

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

Xenon based biosensors have the potential to detect and localizebiomarkers associated with a wide variety of diseases. The development andnuclearmagnetic resonance (NMR) characterization of cage molecules which encapsulatehyperpolarized xenon is imperative for the development of these xenonbiosensors.We acquired 129Xe NMR spectra, and magnetic resonance images and a HyperCESTsaturation map of cucurbit[6]uril (CB6) in whole bovine blood. We observed ameanHyperCEST depletion of 84% (n=5) at a concentration of 5 mM and 74% at 2.5 mM.Additionally, we collected these data using a pulsed HyperCEST saturation pre-pulsetrain with a SAR of 0.025 W/kg which will minimize any potential RF heating inanimalor human tissue.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/