Wiete WESTERHOF,Cornelis Joseph Maria MELIEF,Rosalie Margaretha LUITEN
申请号：
US13493284
公开号：
US20120315304A1
申请日:
2012.06.11
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The metabolization of certain phenols, monophenols or benzenediols into reactive quinone compounds, in particular ortho-quinones and related reactive intermediates, which is brought about by oxidation of monophenols and benzenediols by proteins exhibiting tyrosinase activity, such as human tyrosinase and the related proteins TRP1 and TRP2. The compounds function as haptens that become covalently bound to the tyrosinase enzymes, in particular to histidine moieties, in or near the catalytic site of proteins exhibiting tyrosinase activity, such as tyrosinase, TRP1 and TRP2. An immune response is then to be mounted against these haptenized auto-antigens to treat malignancies.
