DALY,CHRISTOPHER,THURSTON, GAVIN,PAPADOPOULOS, NICHOLAS J.
申请号：
MYPI 2014003097
公开号：
MY164604A
申请日:
2013.06.25
申请国别(地区):
MY
年份:
2018
代理人:
摘要：
THE PRESENT INVENTION PROVIDES ANTIBODIES THAT BIND TO EGFR AND METHODS OF USING SAME. ACCORDING TO CERTAIN EMBODIMENTS OF THE INVENTION, THE ANTIBODIES ARE FULLY HUMAN ANTIBODIES THAT BIND TO HUMAN EGFR WITH HIGH AFFINITY. IN CERTAIN EMBODIMENTS, THE ANTIBODIES OF THE PRESENT INVENTION ARE CAPABLE OF INHIBITING THE GROWTH OF TUMOR CELLS EXPRESSING HIGH LEVELS OF EGFR AND/OR INDUCING ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY (ADCC) OF SUCH CELLS. THE ANTIBODIES OF THE INVENTION ARE USEFUL FOR THE TREATMENT OF VARIOUS CANCERS AS WELL AS OTHER EGFR-RELATED DISORDERS.
